African Journal of Biotechnology. 2011, 10(10):1926-1931
Ventilator-associated pneumonia (VAP) is one of the most common hospital-associated infections and
has accounted for approximately 15% of all hospital-associated infections. In 76% of the VAP cases, the
same bacteria colonize the oral cavity and lungs. Oral care interventions may play a role in the
prevention of VAP, yet more than half of the hospitals do not have specific policies for the oral care of
intubated patients. Oral cavity interlinks with respiratory tracts and digestive tracts. After surgery has
been performed in these areas, aerobic and anaerobic bacteria frequently induce operative wound
infections in teeth, gingiva and supporting tissues of the teeth and tonsils. This study investigates the
effects of a nanotechnology antimicrobial spray (JUC) on the incidence of VAP. 320 patients diagnosed
with VAP were randomly divided into treatment and control groups. After using chlorhexidine
mouthrinse, the treatment group used a nanotechnology antimicrobial spray to the nose and mouth.
The control group was given normal saline. The incidence rate of VAP was significantly lower in the
treatment (8.38%) than control group (54.24%) (p<0.01). A physical antimicrobial film is formed on the
surface of oral and nasal mucosa after using the JUC spray which effectively reduces the microbial
colonization in the sprayed areas, thus reducing and delaying the incidence of VAP.
发布作者: W.LI
发布日期: 2011
关键词: Ventilator-associated pneumonia, oral care, nanotechnology antimicrobial spray, bacterial colonization.
